Buccal thin films that provide steady, reliable delivery through the mucosal tissue. Offers discreet, comfortable adherence and bypasses first-pass metabolism for improved absorption and drug-level consistency.
Steady, sustained drug delivery.
Minimizes GI tract exposure and hepatic processing.
Specialized mucoadhesives for secure placement.
No water needed.
Dissolvable or insoluble options.
Compact, easy-to-use packaging.
Specifications
Slow Eroding Backing
Drug-In Mucoadhesive Matrix
Specifications
Buccal thin films utilize specialized mucoadhesive polymers to adhere to the cheek lining, allowing for controlled drug absorption through the highly vascularized buccal mucosa directly into the systemic circulation.
Place the film against the inner cheek, which adheres to the mucosal tissue.
The film gradually releases the API for absorption through the buccal mucosa.
The drug enters the bloodstream directly, bypassing first-pass metabolism and delivering consistent therapeutic levels.
ARx offers comprehensive support throughout your development journey, from feasibility studies to full-scale production. Backed by decades of experience in mucoadhesive technologies and polymer science, we ensure a reliable, high-quality buccal film product.
Curious how buccal thin films compare to traditional dosage forms? Explore the benefits and find the perfect solution for your unique formulation needs.
Buccal thin films are highly versatile and can deliver a wide range of APIs, particularly those that benefit from bypassing first-pass metabolism. They excel with potent compounds such as hormones, peptides, proteins, cardiovascular drugs, and compounds sensitive to digestive degradation or with narrow therapeutic windows.
Buccal films offer significant advantages: portability with discreet dosing, enhanced bioavailability, rapid onset of drug therapy, potentially reduced dosing frequency, avoidance of hepatic first-pass metabolism, and improved patient adherence. This delivery system creates meaningful differentiation and potential for improved clinical outcomes.
Depending on the formulation design and therapeutic requirements, buccal films can be engineered to provide drug release for 30 minutes to 12 hours. This sustained delivery maintains consistent plasma concentrations and reduces dosing frequency.
Buccal films provide several key benefits: avoidance of first-pass metabolism, rapid drug onset versus the lag time of oral dosing, reduced GI tract irritation, elimination of food effect variability, reduced hepatic burden, lower total drug load, and improved bioavailability leading to better therapeutic outcomes with fewer side effects.
Our buccal films can accommodate various APIs, particularly those benefiting from avoiding first-pass metabolism. We’ve successfully formulated films with cardiovascular drugs, hormones, antiinflammatories, CNS actives, and macromolecules with API loads tailored to specific therapeutic needs.
Our buccal films utilize pharmaceutical-grade muco-adhesive polymers, film formers, plasticizers, and permeation enhancers. All excipients are USP/ NF compendial or GRAS, and specifically selected for compatibility with extended buccal residence.
Yes, our buccal films can be extensively customized for size, mucoadhesive strength, drug release profile, residence time, and taste attributes. We can develop specialized formulations with single or multi-layer systems to accommodate API combinations or sequenced release profiles.
Our development follows a structured approach: feasibility assessment, prototype development, analytical method establishment, in vitro release testing, formulation optimization, stability studies, process scale-up, clinical supplies manufacture, and regulatory documentation. Each phase incorporates quality-by-design principles for successful commercialization.
Buccal thin films are individually packaged in sealed pouches, protecting
them from moisture and oxygen. Depending on formulation specifics, shelf life
typically ranges from 24-36 months at ambient environmental conditions. Most formulations remain stable at room temperature.
Questions about our buccal thin film options? Curious about application for your therapeutic area? Talk to our experts today about your needs.
